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Aβ 40 (Amyloid beta 40) (32A1) Monoclonal Antibody

Aβ 40 (Amyloid beta 40) (32A1) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name 40 (Amyloid beta 40) (32A1) Monoclonal Antibody, A&beta
Also known as 40 (Amyloid beta 40) (32A1) Monoclonal Antibody, A&beta
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigen 40 (Amyloid beta 40), A&beta
Specificity 40 (Amyloid beta 40), This is a highly specific antibody against A&beta
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number32A1
SourceSynthetic peptide
Gene ID number351
Swiss ProtP05067
Tested ApplicationsWB
Recommended dilutions000), WB (1:2
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a kinesin I membrane receptor, Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses, Beta-amyloid 42 is a more effective reductant than beta-amyloid 40, Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity, Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, Bind transient metals such as copper, Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, In vitro, In vitro, Induces a AGER-dependent pathway that involves activation of p38 MAPK, Inhibits G(o) alpha ATPase activity (By similarity), Involved in cell mobility and transcription regulation through protein-protein interactions, Involved in copper homeostasis/oxidative stress through copper ion reduction, Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1, The splice isoforms that contain the BPTI domain possess protease inhibitor activity, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation, inhibiting metal-catalyzed oxidation of lipoproteins, mediating the axonal transport of beta-secretase and presenilin 1, neuronal adhesion and axonogenesis, respectively, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons, zinc and iron, Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth
Purification methodAmmonium sulfate precipitation
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names A4, ABETA, ABPP, AD1, APP, APPI, Alzheimer disease amyloid protein, Amyloid beta A4 protein, Amyloid precursor protein, Beta-amyloid precursor protein, CTFgamma, CVAP, Cerebral vascular amyloid peptide, PN-II, PN2, PreA4, Protease nexin-II, AAA
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target 40 (Amyloid beta 40) (32A1) Monoclonal, A&beta
Short name 40 (Amyloid beta 40) (32A1) Monoclonal Antibody, A&beta
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name 40 (Amyloid b 40) (32A1) monoclonal (Antibody to), A&beta
Alternative techniqueantibodies

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