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Ack1 Antibody

Ack1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAck1 Primary Polyclonal Antibody
Also known asAck1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAck1
SpecificityThis is a highly specific antibody against Ack1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range320-370/1055
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Ack1
Gene ID number10188
Swiss ProtQ07912
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AR, Activates AKT1 by phosphorylating it on 'Tyr-176', Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Contributes to the control of AXL receptor levels, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, MCF2, May be involved both in adult synaptic function and plasticity and in brain development, Phosphorylates AKT1, Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates MCF2, Phosphorylates WWOX on 'Tyr-287', Transduces extracellular signals to cytosolic and nuclear effectors, WASL and WWOX, cell growth and proliferation, cell survival, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ACK-1, ACK1, Activated CDC42 kinase 1, TNK2, Tyrosine kinase non-receptor protein 2, p21cdc42Hs, ACK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAck1
Short nameAck1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAck1 (Antibody to)
Alternative techniqueantibodies
Identity 19297
Gene TNK2
Long gene name tyrosine kinase non receptor 2
Synonyms gene name 2 , non-receptor, tyrosine kinase
Synonyms p21cdc42Hs ACK ACK1
Synonyms name activated Cdc42-associated kinase 1
Locus 3q29
Discovery year 2005-01-19
GenBank acession L13738
Entrez gene record 10188
Pubmed identfication 8497321 14506255
RefSeq identity NM_005781
Havana BLAST/BLAT OTTHUMG00000155737

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