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Ack1 Antibody, ALEXA FLUOR 350

Ack1 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, Ack1 Polyclonal Antibody
Also known asAnti-Ack1 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAck1
SpecificityThis is a highly specific antibody against Ack1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range320-370/1055
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Ack1
Gene ID Number10188
Swiss ProtQ07912
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen AR, Activates AKT1 by phosphorylating it on 'Tyr-176', Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Contributes to the control of AXL receptor levels, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, MCF2, May be involved both in adult synaptic function and plasticity and in brain development, Phosphorylates AKT1, Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates MCF2, Phosphorylates WWOX on 'Tyr-287', Transduces extracellular signals to cytosolic and nuclear effectors, WASL and WWOX, cell growth and proliferation, cell survival, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms p21cdc42Hs ACK ACK1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetAck1
Short nameAck1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, Ack1 (Antibody to)
Alternative techniqueantibodies
Identity 19297
Gene TNK2
Long gene name tyrosine kinase non receptor 2
Synonyms gene name 2 , non-receptor, tyrosine kinase
Synonyms name activated Cdc42-associated kinase 1
Locus 3q29
Discovery year 2005-01-19
GenBank acession L13738
Entrez gene record 10188
Pubmed identfication 8497321 14506255
RefSeq identity NM_005781
Havana BLAST/BLAT OTTHUMG00000155737

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