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Ack1 (Tyr284) Antibody

Ack1 (Tyr284) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAck1 (Tyr284) Primary Polyclonal Antibody
Also known asAck1 (Tyr284) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAck1 Tyr284
Specificity This phosphorylation site is homologous to the Tyr284 site in Mouse and Rat, This is a highly specific antibody against Ack1 Tyr284
Modification(s)Phosphorylation
Modification site(s)Tyr284
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range260-310/1055
Subcellular location Membrane bound, Nucleus
SourceKLH conjugated synthetic phosphopeptide derived from mouse Ack1 around the phosphorylation site of Tyr284
Gene ID number51789
Swiss ProtO54967
Tested Applications FCM, IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AR, Activates AKT1 by phosphorylating it on 'Tyr-176', Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Contributes to the control of AXL receptor levels, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, MCF2, May be involved both in adult synaptic function and plasticity and in brain development, Phosphorylates AKT1, Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates MCF2, Phosphorylates WWOX on 'Tyr-287', Transduces extracellular signals to cytosolic and nuclear effectors, WASL and WWOX, cell growth and proliferation, cell survival, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Ack-1, Ack1, Activated CDC42 kinase 1, Cdgip, Non-receptor protein tyrosine kinase Ack, Pyk1, Tnk2, Tyrosine kinase non-receptor protein 2, Ack
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAck1 (Tyr284)
Short nameAck1 (Tyr284) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAck1 (Tyr284) (Antibody to)
Alternative techniqueantibodies

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