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Aconitase 2/ACO2 Antibody

Aconitase 2/ACO2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAconitase 2/ACO2 Primary Polyclonal Antibody
Also known asAconitase 2/ACO2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAconitase 2/ACO2
SpecificityThis is a highly specific antibody against Aconitase 2/ACO2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Aconitase 2
Gene ID number50
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ACO2 activity is dependent on the state of this cluster as well as the presence of two conserved cysteine residues, ACO2 contains a redox-sensitive iron-sulfur cluster that exists in two states: active (Fe4S4) and inactive (Fe3S4), In malignant prostate cells zinc is unable to accumulate, In normal prostate epithelial cells ACO2 activity is prevented due to the high levels of zinc inhibiting the enzyme, In these citrate-producing epithelial cells citrate oxidation is impaired allowing citrate to accumulate and exhibit a citrate:isocitrate ratio of approximately 30:1, It is expressed in the mitochondria and maintains a citrate:isocitrate ratio of approximately 10:1, also referred to as aconitate hydratase, citrate hydrolyase or aconitase, is an iron-sulfur hydrolyase that catalyzes the non-limiting interconversion of citrate and isocitrate in the tricarboxylic acid cycle, therefore ACO2 activity resumes and citrate is oxidized, ACO2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ACO2, ACONM, Aconitase, Aconitase 2 mitochondrial, Aconitase2, Aconitate hydratase, Aconitate hydratase mitochondrial, Citrate hydro lyase, aconitase 2, ACO 2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAconitase 2/ACO2
Short nameAconitase 2/ACO2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAconitase 2/ACO2 (Antibody to)
Alternative techniqueantibodies
Identity 118
Gene ACO2
Long gene name aconitase 2
Synonyms gene name aconitase 2, mitochondrial
Synonyms ACONM
Synonyms name aconitate hydratase, mitochondrial mitochondrial aconitase
Locus 22q13, 2
Discovery year 1986-01-01
GenBank acession AH006514
Entrez gene record 50
Pubmed identfication 10591208
RefSeq identity NM_001098
Havana BLAST/BLAT OTTHUMG00000030544

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