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ACVR2B/ACTR-IIB Antibody

ACVR2B/ACTR-IIB Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameACVR2B/ACTR-IIB Primary Polyclonal Antibody
Also known asACVR2B/ACTR-IIB PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenACVR2B/ACTR-IIB
SpecificityThis is a highly specific antibody against ACVR2B/ACTR-IIB
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range50-100/512
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB
Gene ID number93
Swiss ProtQ13705
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ACVR1B or ACVR1c), Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase, Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary, Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor, FSH production by the pituitary gland, Inhibitory SMAD7, Once activated, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4, Soon after their association with the activin receptor and subsequent phosphorylation, The activated receptor type-2 then phosphorylates and activates the type-1 receptor, The type-1 receptors like ACVR1B act as downstream transducers of activin signals, This SMAD complex translocates into the nucleus where it mediates activin-induced transcription, Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, Within the receptor complex, activin-B/INHBB as well as inhibin-A/INHA-INHBA), can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, extracellular matrix production, hair follicle development and cycling, immunosuppression and carcinogenesis, on serine residues of the C-terminal tail, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, thereby blocking the activin signal, which is recruited to ACVR1B through FKBP1A, wound healing, Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ACTRIIB, ACVR2B, ActR-IIB, Activin receptor type IIB, Activin receptor type-2B, HTX4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetACVR2B/ACTR-IIB
Short nameACVR2B/ACTR-IIB Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameACVR2B/ACTR-IIB (Antibody to)
Alternative techniqueantibodies
Identity 174
Gene ACVR2B
Long gene name activin A receptor type 2B
Synonyms gene name activin A receptor, type IIB
Synonyms ActR-IIB
Locus 3p22, 2
Discovery year 1997-03-19
GenBank acession X77533
Entrez gene record 93
Pubmed identfication 8161782 9621519
RefSeq identity NM_001106
Classification Type 2 receptor serine/threonine kinases
Havana BLAST/BLAT OTTHUMG00000131291

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