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ACVR2B/ACTR-IIB Antibody, Biotin Conjugated

ACVR2B/ACTR-IIB Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, ACVR2B/ACTR-IIB Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenACVR2B/ACTR-IIB
SpecificityThis is a highly specific antibody against ACVR2B/ACTR-IIB
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range50-100/512
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB
Gene ID number93
Swiss ProtQ13705
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background ACVR1B or ACVR1c), Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase, Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary, Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor, FSH production by the pituitary gland, Inhibitory SMAD7, Once activated, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4, Soon after their association with the activin receptor and subsequent phosphorylation, The activated receptor type-2 then phosphorylates and activates the type-1 receptor, The type-1 receptors like ACVR1B act as downstream transducers of activin signals, This SMAD complex translocates into the nucleus where it mediates activin-induced transcription, Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, Within the receptor complex, activin-B/INHBB as well as inhibin-A/INHA-INHBA), can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, extracellular matrix production, hair follicle development and cycling, immunosuppression and carcinogenesis, on serine residues of the C-terminal tail, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, thereby blocking the activin signal, which is recruited to ACVR1B through FKBP1A, wound healing, Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms ActR-IIB
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetACVR2B/ACTR-IIB Conjugated
Short name Conjugated, ACVR2B/ACTR-IIB Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, ACVR2B/ACTR-IIB (Antibody to)
Alternative techniqueantibodies
Identity 174
Gene ACVR2B
Long gene name activin A receptor type 2B
Synonyms gene name activin A receptor, type IIB
Locus 3p22, 2
Discovery year 1997-03-19
GenBank acession X77533
Entrez gene record 93
Pubmed identfication 8161782 9621519
RefSeq identity NM_001106
Classification Type 2 receptor serine/threonine kinases
Havana BLAST/BLAT OTTHUMG00000131291

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