| Long name | ACVRL1 Primary Polyclonal Antibody |
| Also known as | ACVRL1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ACVRL1 |
| Specificity | This is a highly specific antibody against ACVRL1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 30-80/503 |
| Subcellular location | Extracellular |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ALK1 |
| Gene ID number | 94 |
| Swiss Prot | P37023 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | May bind activin as well, On ligand binding, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, then bind and activate SMAD transcriptional regulators, Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ACVRL1, ACVRLK1, ALK-1, ALK1, Activin receptor-like kinase 1, HHT2, ORW2, SKR3, Serine/threonine-protein kinase receptor R3, TGF-B superfamily receptor type I, TSR-I, HHT |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ACVRL1 |
| Short name | ACVRL1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | activin A receptor classification II-like 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ACVRL1 and IDBG-33826 and ENSG00000139567 and 102723650, ACVRLK1 and ALK-1 and ALK1 and HHT and HHT2 and ORW2 and SKR3 and TSR-I, Acvrl1 and IDBG-185502 and ENSMUSG00000000530 and 11482, BT, Cell surfaces, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008015 and blood circulation and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010596 and negative regulation of endothelial cell migration and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016361 and activin receptor activity, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048185 and activin binding and molecular function this GO :0048514 and blood vessel morphogenesis and biological process this GO :0050431 and transforming growth factor beta binding and molecular function this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0060836 and lymphatic endothelial cell differentiation and biological process this GO :0060840 and artery development and biological process this GO :0060841 and venous blood vessel development and biological process this GO :0061154 and endothelial tube morphogenesis and biological process this GO :0061298 and retina vasculature development in camera-type eye and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :0071773 and cellular response to BMP stimulus and biological process this GO :2000279 and negative regulation of DNA biosynthetic process and biological process, spreading of epidermal cells and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043535 and regulation of blood vessel endothelial cell migration and biological process this GO :0043537 and negative regulation of blood vessel endothelial cell migration and biological process this GO :0045602 and negative regulation of endothelial cell differentiation and biological process this GO :0045603 and positive regulation of endothelial cell differentiation and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045893 and positive regulation of transcription, this GO :0001525 and angiogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001936 and regulation of endothelial cell proliferation and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001946 and lymphangiogenesis and biological process this GO :0001955 and blood vessel maturation and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002043 and blood vessel endothelial cell proliferation involved in sprouting angiogenesis and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004675: transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702: receptor signaling protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005024: transforming growth factor beta-activated receptor activity and also this GO :0005025: transforming growth factor beta receptor activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004675: transmembrane receptor protein serine/threonine kinase activity, this GO :0004702: receptor signaling protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005024: transforming growth factor beta-activated receptor activity, this GO :0005025: transforming growth factor beta receptor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016361: activin receptor activity, this GO :0016772: transferase activity, this GO :0019901: protein kinase binding, this GO :0046332: SMAD binding, this GO :0046872: metal ion binding, this GO :0048185: activin binding, this GO :0050431: transforming growth factor beta binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019901: protein kinase binding and also this GO :0046332: SMAD binding and also this GO :0046872: metal ion binding and also this GO :0048185: activin binding and also this GO :0050431: transforming growth factor beta binding, transferring phosphorus-containing groups and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030425 and dendrite and cellular component this GO :0030509 and BMP signaling pathway and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0032332 and positive regulation of chondrocyte differentiation and biological process this GO :0032924 and activin receptor signaling pathway and biological process this GO :0035313 and wound healing, transforming growth factor beta receptor activity, type I, type I, type I and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016361: activin receptor activity, type I and also this GO :0016772: transferase activity, type I and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006275 and regulation of DNA replication and biological process this GO :0006355 and regulation of transcription, type I and molecular function this GO :0016772 and transferase activity, 28710 and IDBG-632173 and ENSBTAG00000013843 and 534536, 94, activin A receptor type II-like 1 |
| Identity | 175 |
| Gene | ACVRL1 |
| Long gene name | activin A receptor like type 1 |
| Synonyms gene | ACVRLK1 ORW2 |
| Synonyms gene name | activin A receptor type II-like 1 activin A receptor type IL |
| Synonyms | HHT2 ALK1 HHT |
| Locus | 12q13, 13 |
| Discovery year | 1994-12-12 |
| GenBank acession | L17075 |
| Entrez gene record | 94 |
| Pubmed identfication | 8397373 8640225 22718755 |
| RefSeq identity | NM_000020 |
| Classification | Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT | OTTHUMG00000169507 |
| Locus Specific Databases | Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database LRG_543 |
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