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ADAM10 Antibody, Cy7 Conjugated

ADAM10 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, ADAM10 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenADAM10
SpecificityThis is a highly specific antibody against ADAM10
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range623-672/748
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human ADAM10
Gene ID number102
Swiss ProtO14672
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B, Contributes to the normal cleavage of the cellular prion protein, Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis, Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, May regulate the EFNA5-EPHA3 signaling, Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form, Responsible for the proteolytic release of several other cell-surface proteins, Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP), including heparin-binding epidermal growth-like factor, suggesting a vesicle-based protease activity, Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms kuz MADM HsT18717 CD156c
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetADAM10 Conjugated
Short name Conjugated, ADAM10 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, ADAM metallopeptidase domain 10 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target AD10 and AD18 and CD156c and HsT18717 and kuz and MADM and RAK, ADAM10 and IDBG-14155 and ENSG00000137845 and 102, ADAM10 and IDBG-646594 and ENSBTAG00000005481 and 282132, Adam10 and IDBG-182594 and ENSMUSG00000054693 and 11487, nuclei, protein homodimerization activity, this GO :0001701 and in utero embryonic development and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005798 and this GO lgi-associated vesicle and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008219 and cell death and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0042117 and monocyte activation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045087 and innate immune response and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051089 and constitutive protein ectodomain proteolysis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097038 and perinuclear endoplasmic reticulum and cellular component this GO :0097197 and tetraspanin-enriched microdomain and cellular component, this GO :0004175: endopeptidase activity, this GO :0004175: endopeptidase activity and also this GO :0004222: metalloendopeptidase activity and also this GO :0005102: receptor binding and also this GO :0005178: integrin binding and also this GO :0005515: protein binding and also this GO :0008237: metallopeptidase activity and also this GO :0008270: zinc ion binding and also this GO :0017124: SH3 domain binding and also this GO :0019901: protein kinase binding and also this GO :0042803: protein homodimerization activity, this GO :0004222: metalloendopeptidase activity, this GO :0005102: receptor binding, this GO :0005178: integrin binding, this GO :0005515: protein binding, this GO :0008237: metallopeptidase activity, this GO :0008270: zinc ion binding, this GO :0017124: SH3 domain binding, this GO :0019901: protein kinase binding, this GO :0042803: protein homodimerization activity, ADAM metallopeptidase domain 10
Identity 188
Gene ADAM10
Long gene name ADAM metallopeptidase domain 10
Synonyms gene name a disintegrin and metalloproteinase domain 10
Locus 15q21, 3
Discovery year 1997-03-21
GenBank acession AF009615
Entrez gene record 102
Pubmed identfication 9344679 9441766
RefSeq identity NM_001110
Classification ADAM metallopeptidase domain containing CD molecules
Havana BLAST/BLAT OTTHUMG00000132633

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