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ADAM13 Antibody

ADAM13 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameADAM13 Primary Polyclonal Antibody
Also known asADAM13 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenADAM13
SpecificityThis is a highly specific antibody against ADAM13
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from Xenopus laevis ADAM13
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityOther Species
Cross reactive species detailsXenopus laevis
Background of the target antigen A member of the metalloproteinase family containing disintegrin like domains (ADAMs) the functions of ADAM13 are still poorly understood, ADAM13 contains a putative furin cleavage site, ADAM13 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, ADAM13 has been shown to be proteolytically active, ADAM13 is also shed from cells in culture, ADAM13 may also act as a cell attachment molecule, ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase, ADAM13 was also found in liver, EFG like, It is still unclear if any of these ADAMs are species orthologs of Xenopus ADAM13, Predicted mass is 99, Shed ADAM13 is a 52 kD protein, The full length Xenopus ADAM13 sequence codes for a 914 amino acid protein, Xenopus ADAM13 has greatest homology with human ADAM 33 (51% identical), and 97 kD processed forms, and can form complexes with a2 macroglobulin, and intestines from adult Xenopus, and is 46% identical with human or mouse ADAM12 or ADAM19, and is released into the culture media, as well as disintegrin, but glycosylation and cyteine rich regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, but there are significant differences between the related sequences, by binding integrins through the cysteine rich domain amoung many other roles, cleaved aminoterminal from the transmembrane domain, cleaving fibronectin after binding it to the EGF like domain, cysteine rich, heart, in developing Xenopus embryos, on reduced SDS PAGE gels, suggesting it is a competent protease, suggesting that ADAM13 may be a unique protein, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain, transmembrane and Cytoplasmic domains, 749 kD, ADAM13 was first described as a protein expressed in somatic mesoderm and neural crest cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym namesNULL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetADAM13
Short nameADAM13 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameADAM13 (Antibody to)
Alternative techniqueantibodies

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