| Alternative name1 | CSVP, Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE), TNF-alpha Convertase, TNF-alpha-converting Enzyme, Anti-ADAM17 (CD156b |
| Alternative name2 | CSVP, Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE), TNF-alpha Convertase, TNF-alpha-converting Enzyme, ADAM17 (CD156b |
| Alternative name3 | CSVP, Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE), TNF-alpha Convertase, TNF-alpha-converting Enzyme, ADAM17 (CD156b |
| Alternative name4 | ADAM17 |
| Alternative name5 | CSVP, Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE), TNF-alpha Convertase, TNF-alpha-converting Enzyme, Anti -ADAM17 (CD156b |
| Other names | ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, Disintegrin and metalloproteinase domain-containing protein 17, OTTHUMP00000115493, Snake venom-like protease, TNF-alpha convertase, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, TNF-alpha-converting enzyme, alpha, converting enzyme, disintegrin and metalloproteinase domain-containing protein 17, snake venom-like protease, tumor necrosis factor, ADAM17 protein |
| Gene name | N/A |
| Gene name synonims | N/A |
| Other gene names | ADAM17, ADAM18, CD156B, CSVP, CSVP, MGC71942, TACE, TACE, ADAM17 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | IgG |
| Clone | Polyclonal antibody |
| Host organism | Source: Human, Host: Rabbit |
| Species reactivity | Mouse, Rat, Human |
| Specificity and cross-reactivity | Species Crossreactivity: mouse, rat, Recognizes human CDADAM17 |
| Purification method | Affinity Purified by immunoaffinity chromatography |
| Form/Appearance | 0, 02% sodium azide, Supplied as a liquid in PBS |
| Concentration | N/A |
| Storage and shipping | Do Not Freeze, Store productone at +4 degrees Celsius |
| Tested for: | Immunohistochemistry (IHC) |
| Description | Activating enzymes will cut off the domain that is biological active to become functional, If the substrate is DNA they are called restriction enzymes, Enzymes are cleaving the substrate |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene | ADAM17 |
| Gene target | CSVP, Disintegrin Metalloproteinase Domain Protein 17, Snake Venom-like Protease, TACE), TNF-alpha-converting TNF-alpha Convertase, ADAM17 (CD156b |
| Short name | CSVP, Disintegrin Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE) Antibody, TNF-alpha Convertase, TNF-alpha-converting Enzyme, ADAM17 (CD156b |
| Technique | antibodies against human proteins, antibodies for, enzymes, Antibody |
| Alternative name | CSVP, Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TACE) (Antibody to), tumor necrosis factor-a Convertase, tumor necrosis factor-a-converting Enzyme, ADAM metallopeptidase domain 17 (CD156b |
| Alternative technique | antibodies |
| Alternative to gene target | ADAM17 and IDBG-27788 and ENSG00000151694 and 6868, ADAM17 and IDBG-638333 and ENSBTAG00000001141 and 517541, ADAM18 and CD156B and CSVP and NISBD and TACE, Adam17 and IDBG-130508 and ENSMUSG00000052593 and 11491, Cell surfaces, DIF and TNF-alpha and TNFA and TNFSF2, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0045994 and positive regulation of translational initiation by iron and biological process this GO :0046325 and negative regulation of glucose import and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0048566 and embryonic digestive tract development and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0050708 and regulation of protein secretion and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0050796 and regulation of insulin secretion and biological process this GO :0050806 and positive regulation of synaptic transmission and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0050900 and leukocyte migration and biological process this GO :0050901 and leukocyte tethering or rolling and biological process this GO :0050966 and detection of mechanical stimulus involved in sensory perception of pain and biological process this GO :0050995 and negative regulation of lipid catabolic process and biological process this GO :0051023 and regulation of immunoglobulin secretion and biological process this GO :0051044 and positive regulation of membrane protein ectodomain proteolysis and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051222 and positive regulation of protein transport and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051533 and positive regulation of NFAT protein import into nucleus and biological process this GO :0051798 and positive regulation of hair follicle development and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0055037 and recycling endosome and cellular component this GO :0060557 and positive regulation of vitamin D biosynthetic process and biological process this GO :0060559 and positive regulation of calcidiol 1-monooxygenase activity and biological process this GO :0060664 and epithelial cell proliferation involved in salivary gland morphogenesis and biological process this GO :0060693 and regulation of branching involved in salivary gland morphogenesis and biological process this GO :0061048 and negative regulation of branching involved in lung morphogenesis and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process this GO :0071316 and cellular response to nicotine and biological process this GO :0071407 and cellular response to organic cyclic compound and biological process this GO :0071677 and positive regulation of mononuclear cell migration and biological process this GO :0071803 and positive regulation of podosome assembly and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097527 and necroptotic signaling pathway and biological process this GO :1990268 and response to this GO ld nanoparticle and biological process this GO :2000010 and positive regulation of protein localization to cell surface and biological process this GO :2000343 and positive regulation of chemokine (C-X-C motif) ligand 2 production and biological process this GO :2000377 and regulation of reactive oxygen species metabolic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, Extracellular, PDZ domain binding, TNF and IDBG-300259 and ENSG00000232810 and 7124, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, spreading of epidermal cells and biological process this GO :0035625 and epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0045121 and membrane raft and cellular component this GO :0045741 and positive regulation of epidermal growth factor-activated receptor activity and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048536 and spleen development and biological process this GO :0048870 and cell motility and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051272 and positive regulation of cellular component movement and biological process this GO :0055099 and response to high density lipoprotein particle stimulus and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0000060 and protein import into nucleus, this GO :0001666 and response to hypoxia and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002446 and neutrophil mediated immunity and biological process this GO :0002467 and germinal center formation and biological process this GO :0002690 and positive regulation of leukocyte chemotaxis and biological process this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005112 and Notch binding and molecular function this GO :0005138 and interleukin-6 receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030511 and positive regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031659 and positive regulation of cyclin-dependent protein kinase activity involved in G1/S and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032717 and negative regulation of interleukin-8 production and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0033025 and regulation of mast cell apoptotic process and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033627 and cell adhesion mediated by integrin and biological process this GO :0035313 and wound healing, this GO :0002020: protease binding, this GO :0002020: protease binding and also this GO :0005125: cytokine activity and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0042802: identical protein binding and also this GO :0044212: transcription regulatory region DNA binding, this GO :0004222: metalloendopeptidase activity, this GO :0004222: metalloendopeptidase activity and also this GO :0005112: Notch binding and also this GO :0005138: interleukin-6 receptor binding and also this GO :0005178: integrin binding and also this GO :0005515: protein binding and also this GO :0008237: metallopeptidase activity and also this GO :0008270: zinc ion binding and also this GO :0017124: SH3 domain binding and also this GO :0030165: PDZ domain binding, this GO :0005112: Notch binding, this GO :0005125: cytokine activity, this GO :0005138: interleukin-6 receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005178: integrin binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0008237: metallopeptidase activity, this GO :0008270: zinc ion binding, this GO :0017124: SH3 domain binding, this GO :0030165: PDZ domain binding, this GO :0042802: identical protein binding, this GO :0044212: transcription regulatory region DNA binding, transcription regulatory region DNA binding, translocation and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000165 and MAPK cascade and biological process this GO :0000185 and activation of MAPKKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001775 and cell activation and biological process this GO :0001819 and positive regulation of cytokine production and biological process this GO :0001891 and pha this GO cytic cup and cellular component this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002020 and protease binding and molecular function this GO :0002037 and negative regulation of L-glutamate transport and biological process this GO :0002439 and chronic inflammatory response to antigenic stimulus and biological process this GO :0002740 and negative regulation of cytokine secretion involved in immune response and biological process this GO :0002876 and positive regulation of chronic inflammatory response to antigenic stimulus and biological process this GO :0002925 and positive regulation of humoral immune response mediated by circulating immunoglobulin and biological process this GO :0003009 and skeletal muscle contraction and biological process this GO :0005125 and cytokine activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005622 and intracellular and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006927 and transformed cell apoptotic process and biological process this GO :0006952 and defense response and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007254 and JNK cascade and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009314 and response to radiation and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009615 and response to virus and biological process this GO :0009651 and response to salt stress and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0010693 and negative regulation of alkaline phosphatase activity and biological process this GO :0010888 and negative regulation of lipid storage and biological process this GO :0014823 and response to activity and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019722 and calcium-mediated signaling and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030730 and sequestering of triglyceride and biological process this GO :0031334 and positive regulation of protein complex assembly and biological process this GO :0031622 and positive regulation of fever generation and biological process this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032741 and positive regulation of interleukin-18 production and biological process this GO :0032755 and positive regulation of interleukin-6 production and biological process this GO :0032800 and receptor biosynthetic process and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034116 and positive regulation of heterotypic cell-cell adhesion and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0042493 and response to drug and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043122 and regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043242 and negative regulation of protein complex disassembly and biological process this GO :0043243 and positive regulation of protein complex disassembly and biological process this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045071 and negative regulation of viral genome replication and biological process this GO :0045080 and positive regulation of chemokine biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045123 and cellular extravasation and biological process this GO :0045416 and positive regulation of interleukin-8 biosynthetic process and biological process this GO :0045429 and positive regulation of nitric oxide biosynthetic process and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045670 and regulation of osteoclast differentiation and biological process this GO :0045672 and positive regulation of osteoclast differentiation and biological process this GO :0045760 and positive regulation of action potential and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045892 and negative regulation of transcription, tumor necrosis factor, ADAM metallopeptidase domain 17 |
| Identity | 195 |
| Long gene name | ADAM metallopeptidase domain 17 |
| Synonyms gene | TACE |
| Synonyms gene name | alpha, converting enzyme , tumor necrosis factor |
| Synonyms | cSVP CD156B |
| Locus | 2p25, 1 |
| Discovery year | 1997-04-10 |
| GenBank acession | U69611 |
| Entrez gene record | 6868 |
| Pubmed identfication | 9034190 9574564 |
| Classification | ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT | OTTHUMG00000090425 |
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