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ADAR1 Antibody

ADAR1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameADAR1 Primary Polyclonal Antibody
Also known asADAR1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenADAR1
SpecificityThis is a highly specific antibody against ADAR1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range150-200/1226
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ADAR1
Gene ID number103
Swiss ProtP55265
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing), Enhances the replication of MV, Exhibits either a proviral (HDV, Exhibits low-level editing at the GRIA2 Q/R site, Impairs HCV replication via RNA editing at multiple sites, Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), Its viral RNA substrates include: hepatitis C virus (HCV), MV, RNA stability by changing sequences involved in nuclease recognition, Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities, Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence, This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions, and human immunodeficiency virus type 1 (HIV-1), but edits efficiently at the R/G site and HOTSPOT1, editing-independent (VSV and MV) or both (HIV-1), genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, hepatitis delta virus (HDV), measles virus (MV), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3), pre-mRNA splicing by altering splice site recognition sequences, vesicular stomatitis virus (VSV), Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 136 kDa double-stranded RNA-binding protein, ADAR, ADAR1, AGS6, DRADA, DSRAD, Double-stranded RNA-specific adenosine deaminase, G1P1, IFI-4, IFI4, Interferon-inducible protein 4, K88DSRBP, P136, DSH
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetADAR1
Short nameADAR1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameADAR1 (Antibody to)
Alternative techniqueantibodies
Identity 225
Gene ADAR
Long gene name RNA specific , adenosine deaminase
Synonyms gene IFI4 G1P1
Synonyms gene name interferon-induced protein 4
Synonyms ADAR1
Locus 1q21, 3
Discovery year 1995-12-12
GenBank acession BC038227
Entrez gene record 103
Pubmed identfication 7972084
RefSeq identity NM_001111
Classification Adenosine deaminases acting on RNA
Havana BLAST/BLAT OTTHUMG00000037261

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