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ADO Antibody / 2-Aminoethanethiol dioxygenase

ADO Antibody / 2-Aminoethanethiol dioxygenase size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenADO / 2-Aminoethanethiol dioxygenase
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Added buffer025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2
Intented useThis ADO antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q96SZ5
PurityAntigen affinity
Description CDO adds 2 oxygen atoms to free cysteine, It is also noted that the demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity, It is demonstrated that mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine, Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine, Recombinant Ado was shown to bind iron, Similar results were found with human ADO, When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine, Human thiol dioxygenases include cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO)
ImmunogenAmino acids E49-E261 from the human protein were used as the immunogen for the ADO antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ADO antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
Localization membranous, Cytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetADO / 2-Aminoethanethiol dioxygenase
Short nameADO Antibody / 2-Aminoethanethiol dioxygenase
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameADO (Antibody to) / 2-Aminoethanethiol dioxygenase
Alternative techniqueantibodies
Identity 23506
Gene ADO
Long gene name 2-aminoethanethiol dioxygenase
Synonyms gene C10orf22
Synonyms gene name chromosome 10 open reading frame 22 2-aminoethanethiol (cysteamine) dioxygenase
Synonyms FLJ14547
Synonyms name cysteamine dioxygenase
Locus 10q21, 3
Discovery year 2003-11-21
GenBank acession BC028589
Entrez gene record 84890
Pubmed identfication 17581819
RefSeq identity NM_032804
Havana BLAST/BLAT OTTHUMG00000018306

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