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AGER Antibody, ALEXA FLUOR 350

AGER Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, AGER Polyclonal Antibody
Also known asAnti-AGER PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAGER
SpecificityThis is a highly specific antibody against AGER
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range30-80/404
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AGER
Gene ID Number177
Swiss ProtQ15109
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen ABPP-initiated RAGE signaling, AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes, Can also bind oligonucleotides, Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, Interaction with S100A12 on endothelium, Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity), Receptor for amyloid beta peptide, These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, and endothelial dysfunction in type 2 diabetes, and lymphocytes triggers cellular activation, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, mononuclear phagocytes, oxidative stress, with generation of key proinflammatory mediators, Mediates interactions of advanced glycosylation end products (AGE)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms RAGE SCARJ1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetAGER
Short nameAGER Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, advanced glycosylation end product-specific receptor (Antibody to)
Alternative techniqueantibodies
Alternative to gene target AGER and IDBG-633065 and ENSBTAG00000014420 and 280986, AGER and IDBG-80463 and ENSG00000204305 and 177, Ager and IDBG-172144 and ENSMUSG00000015452 and 11596, Extracellular, RAGE, S100 protein binding, this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0009611 and response to wounding and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031175 and neuron projection development and biological process this GO :0042802 and identical protein binding and molecular function this GO :0044548 and S100 protein binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0050930 and induction of positive chemotaxis and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process, this GO :0004872: receptor activity, this GO :0004872: receptor activity and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005515: protein binding and also this GO :0042802: identical protein binding and also this GO :0044548: S100 protein binding, this GO :0004888: transmembrane signaling receptor activity, this GO :0005515: protein binding, this GO :0042802: identical protein binding, this GO :0044548: S100 protein binding, advanced glycosylation end product-specific receptor
Identity 320
Gene AGER
Long gene name advanced glycosylation end-product specific receptor
Synonyms name receptor for advanced glycation end-products
Locus 6p21, 32
Discovery year 1994-10-17
GenBank acession M91211
Entrez gene record 177
Pubmed identfication 7713518
RefSeq identity NM_001136
Classification C2-set domain containing Immunoglobulin like domain containing Scavenger receptors
Havana BLAST/BLAT OTTHUMG00000031120

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