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AKAP12/Gravin Antibody

AKAP12/Gravin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAKAP12/Gravin Primary Polyclonal Antibody
Also known asAKAP12/Gravin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAKAP12/Gravin
SpecificityThis is a highly specific antibody against AKAP12/Gravin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human of human AKAP12
Gene ID number9590
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AKAP12) was cloned from a cDNA expression library screened with serum, Decreased binding of PKCa to gravin was found after activation of PKC, Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell, Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane, In differentiated cells, PKCa and PKA, This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, Upon differentiation of NT2 cells to neurons (NT2 N), cultured fibroblasts and osteosarcoma cells and highly expressed in the brain, from a myasthenia gravis patient, gravin is co-localized with PKCbII, to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals, Gravin (also known as A Kinase Anchor Protein 12
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names A kinase Anchor Protein 12, A kinase anchor protein 250kDa, AKAP 12, AKAP 250, AKAP250, DKFZp686M0430, DKFZp686O0331, Gercelin, Gravin, Kinase scaffold protein gravin, Myasthenia gravis autoantigen gravin, SSeCKS, Srcs5, Tsga12, A kinase PRKA anchor protein gravin 12
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAKAP12/Gravin
Short nameAKAP12/Gravin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAKAP12/Gravin (Antibody to)
Alternative techniqueantibodies
Identity 370
Gene AKAP12
Long gene name A-kinase anchoring protein 12
Synonyms gene name A kinase (PRKA) anchor protein (gravin) 12 A kinase (PRKA) anchor protein 12
Synonyms AKAP250 SSeCKS
Synonyms name gravin Src-Suppressed C Kinase Substrate
Locus 6q25, 1
Discovery year 1999-09-16
GenBank acession U81607
Entrez gene record 9590
Pubmed identfication 9000000
Classification A-kinase anchoring proteins
Havana BLAST/BLAT OTTHUMG00000015833

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