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AKR1C1/2 Antibody

AKR1C1/2 Antibody size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAKR1C1/2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Added buffer025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2
Intented useThis AKR1C1/2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot # P52895, Q04828
PurityAntigen affinity
Description AKR1C1 binds bile acid with high affinity, The AKR1C1 gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14, The enzymes display overlapping but distinct substrate specificity, These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors, Three transcript variants encoding two different isoforms have been found for this gene, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity, which consists of more than 40 known enzymes and proteins, AKR1C1 and AKR1C2 are members of the aldo/keto reductase superfamily
ImmunogenAmino acids M1-K123 from human AKR1C1 were used as the immunogen for the AKR1C1/2 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the AKR1C1/2 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
LocalizationCytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetAKR1C1/2
Short nameAKR1C1/2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAKR1C1/2 (Antibody to)
Alternative techniqueantibodies
Identity 384
Gene AKR1C1
Long gene name aldo-keto reductase family 1 member C1
Synonyms gene DDH1
Synonyms gene name 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) , aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1
Synonyms DDH MBAB DD1 HAKRC
Synonyms name 20-alpha (3-alpha)-hydroxysteroid dehydrogenase , dihydrodiol dehydrogenase 1
Locus 10p15, 1
Discovery year 1994-09-14
GenBank acession D26124
Entrez gene record 1645
Pubmed identfication 8011662
RefSeq identity NM_001353
Classification Aldo-keto reductases
Havana BLAST/BLAT OTTHUMG00000017580

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