| Long name | Akt Primary Polyclonal Antibody |
| Also known as | Akt PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | Akt |
| Specificity | This is a highly specific antibody against Akt |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Source | Synthetased peptide (KLH coupled) corresponding to C-terminal residues of human Akt |
| Gene ID number | 207 |
| Swiss Prot | P31749 |
| Tested Applications | WB |
| Recommended dilutions | WB (1:2000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Akt is activated by PI3 kinase, Akt/PKB can inhibit cell cycle arrest by phosphorylating p21, Akt/PKB controls vital cellular functions such as cell survival/apoptosis, Akt/PKB directly affects the apoptosis pathway by, Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D, Also, BAD, It also acts down-stream from growth factors and hormones, It also can phosphorylate three kinases upstream of SAPK, Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes, One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), PKB) is a serine/threonine protein kinase, Ser473), The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival, The SAPK system consists of two groups of kinases, The involvement of Akt in disease processes like malignancy, and JNK and p38 MAP kinase pathways, and the modulation of transcription factor activity, cell cycle progression and glucose metabolism, for example, including glycogen and protein synthesis, neurodegeneration and abnormal glucose metabolism has also been demonstrated, nuclear factor-kB(NF-kB), targeting the pro-apoptotic Bcl-2 related protein, which has been associated with the control of many cellular processes, which is itself activated by tyrosine kinase (Thr308, Akt(protein kinase B |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | AKT1, CWS6, PKB, PKB alpha, PKB-ALPHA, PRKBA, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC, RAC-ALPHA, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase, AKT |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | Akt |
| Short name | Akt Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Akt (Antibody to) |
| Alternative technique | antibodies |
| Identity | 391 |
| Gene | AKT1 |
| Long gene name | AKT serine/threonine kinase 1 |
| Synonyms gene name | v-akt murine thymoma viral oncogene homolog 1 |
| Synonyms | RAC PKB PRKBA AKT |
| Locus | 14q32, 33 |
| Discovery year | 1986-01-01 |
| GenBank acession | M63167 |
| Entrez gene record | 207 |
| RefSeq identity | NM_005163 |
| Classification | Pleckstrin homology domain containing |
| Havana BLAST/BLAT | OTTHUMG00000170795 |
| Locus Specific Databases | LRG_721 |
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