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ALS2/Alsin Antibody

ALS2/Alsin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameALS2/Alsin Primary Polyclonal Antibody
Also known asALS2/Alsin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenALS2/Alsin
SpecificityThis is a highly specific antibody against ALS2/Alsin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ALS2
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Alsin acts as a guanine nucleotide exchange factor for Rab5, Alsin is a cytosolic protein that is associated with small, Alsin may mediate membrane transport events, The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity, The ALS2 gene encodes the Alsin protein, Therefore, a modulator of the endocytic pathway, a recessive form of amyotrophic lateral sclerosis (ALS2), and a form of complicated hereditary spastic paraplegia (cHSP), including juvenile primary lateral sclerosis (JPLS), infantile onset ascending hereditary spastic paralysis (IAHSP), potentially linking endocytic processes and actin cytoskeleton remodeling, punctate membrane structures, Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ALS2, ALS2CR6, ALS2_HUMAN, ALSJ, Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 juvenile, Amyotrophic lateral sclerosis 2 juvenile chromosome region candidate 6, Amyotrophic lateral sclerosis 2 protein, Amyotrophic lateral sclerosis protein 2, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ, ALS 2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetALS2/Alsin
Short nameALS2/Alsin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameALS2/Alsin (Antibody to)
Alternative techniqueantibodies
Identity 443
Gene ALS2
Long gene name ALS2, alsin Rho guanine nucleotide exchange factor
Synonyms gene ALS2CR6
Synonyms gene name amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6 amyotrophic lateral sclerosis 2 (juvenile)
Synonyms name alsin
Locus 2q33, 1
Discovery year 1992-11-19
GenBank acession AB053305
Entrez gene record 57679
Pubmed identfication 11586298
RefSeq identity NM_020919
Classification Rho guanine nucleotide exchange factors VPS9 domain containing
Havana BLAST/BLAT OTTHUMG00000154507
Locus Specific Databases ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_654

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