AMPK alpha-1 Antibody

AMPK alpha-1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	AMPK alpha-1 Primary Polyclonal Antibody
Also known as	AMPK alpha-1 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	AMPK alpha-1
Specificity	This is a highly specific antibody against AMPK alpha-1
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	5-30/559
Subcellular location	Nucleus, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AMPK alpha-1
Gene ID number	5562
Swiss Prot	Q13131
Tested Applications	WB
Recommended dilutions	WB(1:100-1000)
Cross reactivity	Monkey, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	ACACB, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, AMPK acts via direct phosphorylation of metabolic enzymes, AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, EP300, FOXO3, GYS1, HDAC5, HMGCR and LIPE, HNF4A, In response to reduction of intracellular ATP levels, In response to stress, MEF2C, MLXIPL/ChREBP, PFKFB2 and PFKFB3, RPTOR and ATG1/ULK1: in response to nutrient limitation, Regulates insulin-signaling and glycolysis by phosphorylating IRS1, Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, SREBF1, SREBF2 and PPARGC1A, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism, and by longer-term effects via phosphorylation of transcription regulators, as well as cell growth and proliferation, carbohydrate and lipid biosynthesis, histone H2B, leading to CRTC2/TORC2 sequestration in the cytoplasm, leading to promote transcription, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2, p53/TP53, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), possibly by mediating phosphorylation of TBC1D4/AS160, probably by indirectly activating myosin, regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively, Catalytic subunit of AMP-activated protein kinase (AMPK)
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	5'-AMP-activated protein kinase catalytic subunit alpha-1, ACACA kinase, AMPK subunit alpha-1, AMPK1, AMPKa1, Acetyl-CoA carboxylase kinase, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA1, Tau-protein kinase PRKAA1, AMPK
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	AMPK alpha-1
Short name	AMPK alpha-1 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	AMPK a-1 (Antibody to)
Alternative technique	antibodies
Identity	9377
Gene	PRKAA2
Long gene name	protein kinase AMP-activated catalytic subunit alpha 2
Synonyms gene	PRKAA
Synonyms gene name	AMP-activated, alpha 2 catalytic subunit , protein kinase
Synonyms	AMPK AMPKa2
Locus	1p32, 2
Discovery year	1995-12-12
GenBank acession	BC069823
Entrez gene record	5563
Pubmed identfication	7959015
RefSeq identity	NM_006252
Havana BLAST/BLAT	OTTHUMG00000008282

AMPK alpha-1 Antibody

AMPK alpha-1 Antibody size: 0.1ml 263

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