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Amyloid Precursor Protein(Y757) Antibody, Cy7 Conjugated

Amyloid Precursor Protein(Y757) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Amyloid Precursor Protein(Y757) Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAmyloid Precursor Protein Tyr757
Specificity This phosphorylation site is homologous in the listed cross reactive species, This is a highly specific antibody against Amyloid Precursor Protein Tyr757
ModificationPhosphorylation
Modification siteTyr757
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range730-770/770
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human APP around the phosphorylation site of Tyr757
Gene ID number351
Swiss ProtP05067
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a kinesin I membrane receptor, Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses, Beta-amyloid 42 is a more effective reductant than beta-amyloid 40, Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity, Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, Bind transient metals such as copper, Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, In vitro, In vitro, Induces a AGER-dependent pathway that involves activation of p38 MAPK, Inhibits G(o) alpha ATPase activity (By similarity), Involved in cell mobility and transcription regulation through protein-protein interactions, Involved in copper homeostasis/oxidative stress through copper ion reduction, Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1, The splice isoforms that contain the BPTI domain possess protease inhibitor activity, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation, inhibiting metal-catalyzed oxidation of lipoproteins, mediating the axonal transport of beta-secretase and presenilin 1, neuronal adhesion and axonogenesis, respectively, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons, zinc and iron, Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms A4, ABETA, ABPP, AD1, APP, APPI, Alzheimer disease amyloid protein, Amyloid beta A4 protein, CTFgamma, CVAP, Cerebral vascular amyloid peptide, PN-II, PN2, PreA4, Protease nexin-II, AAA
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Description also called a , is a type of partially differentiated, usually , Precursor cell, blast, blast cell , cell that has lost most or all of the , multipotency, or simply , stem cell , unipotent 
Gene targetAmyloid Precursor Protein(Y757) Conjugated
Short name Conjugated, Amyloid Protein(Y757) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Amyloid Precursor Protein(Y757) (Antibody to)
Alternative techniqueantibodies

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