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Anti-ADAM11 (Polyclonal), ALEXA Fluor 594

Anti-ADAM11 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideADAM11
SpecificityThis antibody reacts specifically with ADAM11
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human ADAM11
Gene ID4185
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), ADAM11 null mutant mice have deficits in spatial learning and motor coordination, ADAM11 was mapped to 17q21, Another group identified ADAM11 in the human brain, EGF-like domain, Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, The domain structure of the full-length ADAM11 includes a signal sequence, The message was found only in the brain in this publication, Two splice variants with different carboxyterminal ends were described, a human embryonic carcinoma cell line, a region of interest for breast cancer, a spacer region, although they did have normal cell migration and differentiation during development, and mutations in ADAM11 are associated with some breast cancers, but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site, cys-rich domain, disintegrin-like domain, in search of brain-specific proteins, metalloproteinase-like domain, propeptide domain, then the transmembrane domain and a short cytoplasmic domain, where ADAM11 was thought to be involved in cell migration and spatial patterning, 3, ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asADAM11 Polyclonal Antibody
Other nameAnti-ADAM11 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetADAM11
Short nameAnti-ADAM11 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-ADAM metallopeptidase domain 11 (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target ADAM11 and IDBG-54231 and ENSG00000073670 and 4185, ADAM11 and IDBG-640987 and ENSBTAG00000001735 and 522375, Adam11 and IDBG-212766 and ENSMUSG00000020926 and 11488, Extracellular, MDC, this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0031012 and extracellular matrix and cellular component, this GO :0004222: metalloendopeptidase activity, this GO :0004222: metalloendopeptidase activity and also this GO :0005178: integrin binding and also this GO :0005515: protein binding and also this GO :0008237: metallopeptidase activity and also this GO :0008270: zinc ion binding, this GO :0005178: integrin binding, this GO :0005515: protein binding, this GO :0008237: metallopeptidase activity, this GO :0008270: zinc ion binding, zinc ion binding, ADAM metallopeptidase domain 11
Identity 189
Gene ADAM11
Long gene name ADAM metallopeptidase domain 11
Synonyms gene MDC
Synonyms gene name a disintegrin and metalloproteinase domain 11
Synonyms name cysteine-rich protein , disintegrin-like, metalloproteinase-like
Locus 17q21, 31
Discovery year 1993-11-01
GenBank acession D17390
Entrez gene record 4185
Pubmed identfication 8252040
RefSeq identity NM_002390
Classification ADAM metallopeptidase domain containing
Havana BLAST/BLAT OTTHUMG00000179038

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