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Anti-ADAR1 (Polyclonal), ALEXA Fluor 594

Anti-ADAR1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideADAR1
SpecificityThis antibody reacts specifically with ADAR1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from human ADAR1
Gene ID103
Swiss ProtP55265
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive speciesHuman (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing), Enhances the replication of MV, Exhibits either a proviral (HDV, Exhibits low-level editing at the GRIA2 Q/R site, Impairs HCV replication via RNA editing at multiple sites, Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), Its viral RNA substrates include: hepatitis C virus (HCV), MV, RNA stability by changing sequences involved in nuclease recognition, Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities, Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence, This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions, and human immunodeficiency virus type 1 (HIV-1), but edits efficiently at the R/G site and HOTSPOT1, editing-independent (VSV and MV) or both (HIV-1), genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, hepatitis delta virus (HDV), measles virus (MV), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3), pre-mRNA splicing by altering splice site recognition sequences, vesicular stomatitis virus (VSV), Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms ADAR1
Also known asADAR1 Polyclonal Antibody
Other nameAnti-ADAR1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetADAR1
Short nameAnti-ADAR1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-ADAR1 (polyclonal)
Alternative techniquepolyclonals
Identity 225
Gene ADAR
Long gene name RNA specific , adenosine deaminase
Synonyms gene IFI4 G1P1
Synonyms gene name interferon-induced protein 4
Locus 1q21, 3
Discovery year 1995-12-12
GenBank acession BC038227
Entrez gene record 103
Pubmed identfication 7972084
RefSeq identity NM_001111
Classification Adenosine deaminases acting on RNA
Havana BLAST/BLAT OTTHUMG00000037261

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