Anti-AE2 (Polyclonal), ALEXA Fluor 594

Anti-AE2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	AE2
Specificity	This antibody reacts specifically with AE2
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Extracellular
Antigen Source	KLH conjugated synthetic peptide derived from human AE2/SLC4A2
Gene ID	6522
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, The AE2 protein regulates pH, The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow, cell volume and transepithelial ion transport in many tissues, chloride concentration, including hormones, innervation/neuropeptides and biliary constituents, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis, Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	AE2
Also known as	AE2 Polyclonal Antibody
Other name	Anti-AE2 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	AE2
Short name	Anti-AE2 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-AE2 (polyclonal)
Alternative technique	polyclonals
Identity	25076
Gene	NBPF3
Long gene name	neuroblastoma breakpoint family member 3
Synonyms gene name	member 3 , neuroblastoma breakpoint family
Locus	1p36, 12
Discovery year	2005-11-23
GenBank acession	BC024011
Entrez gene record	84224
Pubmed identfication	11230166 16079250
RefSeq identity	NM_032264
Classification	Neuroblastoma breakpoint family
Havana BLAST/BLAT	OTTHUMG00000002944

Anti-AE2 (Polyclonal), ALEXA Fluor 594

Anti-AE2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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