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Anti-AKT3 (Ser472) (Polyclonal), ALEXA Fluor 594

Anti-AKT3 (Ser472) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideAKT3 (Ser472)
SpecificityAKT3 (Ser472), This antibody will cross react with Akt1 when phosphorylated at Ser473 and Akt2 when phosphorylated at Ser474
ModificationPhosphorylation
Modification siteSer472
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human AKT3 around the phosphorylation site of Ser472
Gene ID10000
Swiss ProtQ9Y243
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information AKT2 and AKT3) called the AKT kinase, AKT3 is the least studied AKT isoform, AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13, Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, It plays an important role in brain development and is crucial for the viability of malignant glioma cells, Over 100 substrate candidates have been reported so far, Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands, This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates, and which regulate many processes including metabolism, but for most of them, cell survival, growth and angiogenesis, no isoform specificity has been reported, proliferation, resulting in the induction of caspase-dependent apoptosis, AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms PKBG RAC-gamma PRKBG
Also known asAKT3 (Ser472) Polyclonal Antibody
Other nameAnti-AKT3 (Ser472) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetAKT3 (Ser472)
Short nameAnti-AKT3 (Ser472) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-AKT3 (Ser472) (polyclonal)
Alternative techniquepolyclonals
Identity 393
Gene AKT3
Long gene name AKT serine/threonine kinase 3
Synonyms gene name v-akt murine thymoma viral oncogene homolog 3
Synonyms name gamma , protein kinase B
Locus 1q43-q44
Discovery year 1999-11-16
GenBank acession AF124141
Entrez gene record 10000
Pubmed identfication 10092583 10208883
RefSeq identity NM_181690
Classification Pleckstrin homology domain containing
Havana BLAST/BLAT OTTHUMG00000039994

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