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Anti-APEX2 (Polyclonal), ALEXA Fluor 594

Anti-APEX2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideAPEX2
SpecificityThis antibody reacts specifically with APEX2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Mitochondrion, Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from human APEX2
Gene ID27301
Swiss ProtQ9UBZ4
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information 3'-phosphodiesterase activities, Displays also double-stranded DNA 3'-5' exonuclease, In the nucleus functions in the PCNA-dependent BER pathway, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Required for proper cell cycle progression during proliferation of peripheral lymphocytes, Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes, Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents, Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms APEXL2 APE2 XTH2 ZGRF2
Also known asAPEX2 Polyclonal Antibody
Other nameAnti-APEX2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetAPEX2
Short nameAnti-APEX2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-APEX2 (polyclonal)
Alternative techniquepolyclonals
Identity 17889
Gene APEX2
Long gene name apurinic/apyrimidinic endodeoxyribonuclease 2
Synonyms gene name APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Synonyms name GRF-type containing 2 , zinc finger
Locus Xp11, 21
Discovery year 2002-07-22
GenBank acession AB021260
Entrez gene record 27301
Pubmed identfication 11376153
Classification Zinc fingers GRF-type
Havana BLAST/BLAT OTTHUMG00000021642
Locus Specific Databases Mental Retardation database

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