Anti-Aph-1b (Polyclonal), ALEXA Fluor 594

Anti-Aph-1b (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	Aph-1b
Specificity	This antibody reacts specifically with Aph-1b
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human Aph-1b
Gene ID	83464
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Aph-1b and Aph-1a are splice variants of Aph-1, Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, Aph-1b may execute redundant functions in the cell, Aph-1b specifically lacks exon 4, Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, and is involved in multiple neurodevelopmental signaling pathways, causing the protein to be destabilized, however deficiency of Aph-1b does not, including the beta-Amyloid precursor protein, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex, such as schizophrenia, thus, which encodes for the entire fourth transmembrane domain, Anterior pharynx defective 1 (Aph-1) is a polytopic
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	PSFL APH-1B DKFZp564D0372
Also known as	Aph-1b Polyclonal Antibody
Other name	Anti-Aph-1b Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	Aph-1b
Short name	Anti-Aph-1b (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-Aph-1b (polyclonal)
Alternative technique	polyclonals
Identity	24080
Gene	APH1B
Long gene name	aph-1 homolog B, gamma-secretase subunit
Synonyms gene name	anterior pharynx defective 1 homolog B (C, elegans) APH1B gamma secretase subunit
Locus	15q22, 2
Discovery year	2005-02-08
GenBank acession	AY358698
Entrez gene record	83464
Pubmed identfication	12110170 11230166
RefSeq identity	NM_031301
Havana BLAST/BLAT	OTTHUMG00000132863

Anti-Aph-1b (Polyclonal), ALEXA Fluor 594

Anti-Aph-1b (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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