Name : Anti-Apolipoprotein B (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :489
SKU : GEN9480451595
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | ApoB |
| Specificity | This antibody reacts specifically with Apolipoprotein B |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Cytoplasm |
| Antigen Source | KLH conjugated synthetic peptide derived from human Apolipoprotein B |
| Gene ID | 338 |
| Swiss Prot | N/A |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor, Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia, FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD), LDL (apo B-100) and VLDL (apo B-100), The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors, and dietary fat malabsorption, Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB), Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Also known as | Apolipoprotein B Polyclonal Antibody |
| Other name | Anti-Apolipoprotein B Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | Apolipoprotein B |
| Short name | Anti-Apolipoprotein B (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-Apolipoprotein B (polyclonal) |
| Alternative technique | polyclonals |
| Identity | 603 |
| Gene | APOB |
| Long gene name | apolipoprotein B |
| Synonyms gene name | apolipoprotein B (including Ag(x) antigen) |
| Locus | 2p24, 1 |
| Discovery year | 2001-06-22 |
| GenBank acession | M14162 |
| Entrez gene record | 338 |
| Classification | Apolipoproteins |
| Havana BLAST/BLAT | OTTHUMG00000090785 |