Anti-ARA24 (Polyclonal), ALEXA Fluor 594

Anti-ARA24 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	ARA24
Specificity	This antibody reacts specifically with ARA24
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human ARA24
Gene ID	5901
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Because of its many functions, Mutations in Ran disrupt DNA synthesis, Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1), Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy), RCC1 generates a high local concentration of Ran-GTP around chromatin which, Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, Ran could be a key signaling molecule regulating microtubule polymerization during mitosis, Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor, Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules, The Ran protein is also involved in control of DNA synthesis and cell cycle progression, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease, in turn, induces the local nucleation of microtubules, it is likely that Ran interacts with several other proteins, Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	ARA24 TC4 Gsp1
Also known as	ARA24 Polyclonal Antibody
Other name	Anti-ARA24 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	ARA24
Short name	Anti-ARA24 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-ARA24 (polyclonal)
Alternative technique	polyclonals
Identity	9846
Gene	RAN
Long gene name	RAN, member RAS oncogene family
Locus	12q24, 33
Discovery year	1996-11-14
GenBank acession	M31469
Entrez gene record	5901
Pubmed identfication	8421051
RefSeq identity	NM_006325
Classification	RAN family GTPases
Havana BLAST/BLAT	OTTHUMG00000134328

Anti-ARA24 (Polyclonal), ALEXA Fluor 594

Anti-ARA24 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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