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Anti-ATRIP (Ser68+Ser72) (Polyclonal), ALEXA Fluor 594

Anti-ATRIP (Ser68+Ser72) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideATRIP Ser68+Ser72
SpecificityThis antibody reacts specifically with ATRIP (Ser68+Ser72)
ModificationPhosphorylation
Modification siteSer68+Ser72
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human ATRIP around the phosphorylation site of Ser68 + Ser72 [LA(p-S)QAL(p-S)QC]
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information ATM and ATR kinases are important for cell cycle checkpoint response signalling, ATR-interacting protein (ATRIP), ATRIP is a nuclear protein that may also play a role in protein stabilization, ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR, After dimerization they bind the RPA complex and are recruited to single stranded DNA, Checkpoint proteins include Rad17, Chk2, In response to DNA damage, It is also important for ATR expression, Rad1, Rad9 and Hus1, also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage, which are involved in regulating cell cycle arrest at the G2 checkpoint, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, which regulates DNA replication and damage checkpoint responses, DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms FLJ12343 MGC20625 MGC21482 MGC26740
Also known asATRIP (Ser68+Ser72) Polyclonal Antibody
Other nameAnti-ATRIP (Ser68+Ser72) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetATRIP (Ser68+Ser72)
Short nameAnti-ATRIP (Ser68+Ser72) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-ATRIP (Ser68+Ser72) (polyclonal)
Alternative techniquepolyclonals
Identity 33499
Gene ATRIP
Long gene name ATR interacting protein
Locus 3p21, 31
Discovery year 2007-06-20
GenBank acession AF451323
Entrez gene record 84126
Pubmed identfication 11721054
RefSeq identity NM_130384
Havana BLAST/BLAT OTTHUMG00000133532

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