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Anti-BAP1 (Ser592) (Polyclonal), ALEXA Fluor 594

Anti-BAP1 (Ser592) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideBAP1 Ser592
SpecificityBAP1 (Ser592), This phosphorylation site is homologous to the Ser590 site in Rat
ModificationPhosphorylation
Modification siteSer592
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
Gene ID8314
Swiss ProtQ92560
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, Acts as a tumor suppressor, Catalytic component of the PR-DUB complex, Deubiquitination of HCFC1 does not lead to increase stability of HCFC1, Does not deubiquitinate monoubiquitinated histone H2B, Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination, It however does not mediate deubiquitination of BRCA1 and BARD1, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1), thereby protecting it from cytoplasmic sequestration (PubMed:24703950), with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains, Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms hucep-6 KIAA0272 UCHL2
Also known asBAP1 (Ser592) Polyclonal Antibody
Other nameAnti-BAP1 (Ser592) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetBAP1 (Ser592)
Short nameAnti-BAP1 (Ser592) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-BAP1 (Ser592) (polyclonal)
Alternative techniquepolyclonals
Identity 950
Gene BAP1
Long gene name BRCA1 associated protein 1
Synonyms gene name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Synonyms name ubiquitin carboxy-terminal hydrolase
Locus 3p21, 1
Discovery year 1998-09-17
GenBank acession AF045581
Entrez gene record 8314
Pubmed identfication 9528852
Classification Ubiquitin C-terminal hydrolases
Havana BLAST/BLAT OTTHUMG00000158392
Locus Specific Databases LRG_529

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