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Anti-BCL2L1 (Polyclonal), ALEXA Fluor 594
Anti-BCL2L1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489
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BIOSS POLYCLONAL ANTIBODIES
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489
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100 microliters
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| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | BCL2L1 |
| Specificity | This antibody reacts specifically with BCL2L1 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Helical |
| Antigen Source | KLH conjugated synthetic peptide derived from human BCL2L1 |
| Gene ID | 598 |
| Swiss Prot | Q07817 |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis, Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, During synaptic stimulation, Inhibits activation of caspases, Isoform Bcl-X(L) also regulates presynaptic plasticity, Isoform Bcl-X(S) promotes apoptosis, from the mitochondrial membrane, including neurotransmitter release and recovery, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F() activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles, number of axonal mitochondria as well as size and number of synaptic vesicle clusters, Potent inhibitor of cell death |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | BCLX BCL2L Bcl-X bcl-xL bcl-xS PPP1R52 |
| Also known as | BCL2L1 Polyclonal Antibody |
| Other name | Anti-BCL2L1 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | BCL2L1 |
| Short name | Anti-BCL2L1 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-B-cell CLL/lymphoma 2-like 1 (polyclonal) |
| Alternative technique | polyclonals |
| Alternative to gene target | BCL2L1 and IDBG-63673 and ENSG00000171552 and 598, BCL2L1 and IDBG-641541 and ENSBTAG00000006526 and 282152, BH3 domain binding, Bcl-X and bcl-xL and BCL-XL/S and bcl-xS and BCL2L and BCLX and BCLXL and BCLXS and PPP1R52, Bcl2l1 and IDBG-209867 and ENSMUSG00000007659 and 12048, leucine rich repeat containing receptor signaling pathway and biological process this GO :0040007 and growth and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046898 and response to cycloheximide and biological process this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051402 and neuron apoptotic process and biological process this GO :0051434 and BH3 domain binding and molecular function this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0060154 and cellular process regulating host cell cycle in response to virus and biological process this GO :0070584 and mitochondrion morphogenesis and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process this GO :0071312 and cellular response to alkaloid and biological process this GO :0071480 and cellular response to gamma radiation and biological process this GO :0071839 and apoptotic process in bone marrow and biological process this GO :0090005 and negative regulation of establishment of protein localization to plasma membrane and biological process this GO :0090201 and negative regulation of release of cytochrome c from mitochondria and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :1902230 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, nuclei, this GO :0000910 and cytokinesis and biological process this GO :0001541 and ovarian follicle development and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006897 and endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007093 and mitotic cell cycle checkpoint and biological process this GO :0007281 and germ cell development and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0009314 and response to radiation and biological process this GO :0009566 and fertilization and biological process this GO :0009615 and response to virus and biological process this GO :0010507 and negative regulation of autophagy and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019050 and suppression by virus of host apoptotic process and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0030672 and synaptic vesicle membrane and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0034097 and response to cytokine and biological process this GO :0035872 and nucleotide-binding domain, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0042802: identical protein binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity and also this GO :0051434: BH3 domain binding, this GO :0019901: protein kinase binding, this GO :0042802: identical protein binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, this GO :0051434: BH3 domain binding, BCL2-like 1 |
| Identity | 992 |
| Gene | BCL2L1 |
| Long gene name | BCL2 like 1 |
| Synonyms name | protein phosphatase 1, regulatory subunit 52 |
| Locus | 20q11, 21 |
| Discovery year | 1997-10-30 |
| GenBank acession | Z23115 |
| Entrez gene record | 598 |
| Pubmed identfication | 8358789 |
| RefSeq identity | NM_138578 |
| Classification | Protein phosphatase 1 regulatory subunits BCL2 family |
| Havana BLAST/BLAT | OTTHUMG00000032192 |