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Anti-BRCC36 (Polyclonal), ALEXA Fluor 594

Anti-BRCC36 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideBRCC36
SpecificityThis antibody reacts specifically with BRCC36
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human BRCC3/BRCC36
Gene ID79184
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Catalytic subunit of the BRISC complex, Component of the BRCA1-A complex, Does not have activity toward 'Lys-48'-linked polyubiquitin chains, In the BRCA1-A complex, Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs), it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), via the interaction of the BRISC complex with the CSN complex, Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms C6, 1A BRCC36
Also known asBRCC36 Polyclonal Antibody
Other nameAnti-BRCC36 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetBRCC36
Short nameAnti-BRCC36 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-BRCC36 (polyclonal)
Alternative techniquepolyclonals
Identity 24185
Gene BRCC3
Long gene name BRCA1/BRCA2-containing complex subunit 3
Synonyms gene CXorf53
Synonyms gene name chromosome X open reading frame 53 BRCA1/BRCA2-containing complex, subunit 3
Synonyms name Lys-63-specific deubiquitinase
Locus Xq28
Discovery year 2004-12-03
GenBank acession X64643
Entrez gene record 79184
Pubmed identfication 1303175 14636569
RefSeq identity NM_024332
Classification BRISC complex BRCA1 A complex
Havana BLAST/BLAT OTTHUMG00000022658

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