Filters

Anti-BRCC45 (Polyclonal), ALEXA Fluor 594

Anti-BRCC45 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideBRCC45
SpecificityThis antibody reacts specifically with BRCC45
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human BRCC45
Gene ID9577
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information At least three isoforms of BRCC45 are known to exist, BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway, Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36, This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage, suggesting that BRCC45 may promote tumorigenesis when overexpressed, BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms BRCC45 BRCC4
Also known asBRCC45 Polyclonal Antibody
Other nameAnti-BRCC45 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetBRCC45
Short nameAnti-BRCC45 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-BRCC45 (polyclonal)
Alternative techniquepolyclonals
Identity 1106
Gene BRE
Long gene name brain and reproductive organ-expressed (TNFRSF1A modulator)
Synonyms name BRCA1/BRCA2-containing complex, subunit 4
Locus 2p23, 2
Discovery year 1999-04-23
GenBank acession AF015767
Entrez gene record 9577
Pubmed identfication 9737713 7826398
Classification BRISC complex BRCA1 A complex
Havana BLAST/BLAT OTTHUMG00000097831

Similar products

Subscribe to our Newsletter