Name : Anti-CK II alpha (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :489
SKU : GEN6414180330
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | CK II alpha |
| Specificity | This antibody reacts specifically with CK II alpha |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Nucleus, Cytoplasm |
| Antigen Source | KLH conjugated synthetic peptide derived from human CK II alpha |
| Gene ID | 1457 |
| Swiss Prot | P68400 |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | ATF1, Acts as an ectokinase that phosphorylates several extracellular proteins, Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, Also required for p53/TP53-mediated apoptosis, CMV and HPV, CREB1, Can also negatively regulate apoptosis, During mitosis, During viral infection, FOS, HBV, HCV, HIV, HSV, II, III and IV, IRF1, IRF2, JUN, MAX, MYC and MYB, May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response, Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation, Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3, Phosphorylation protects CASP9 from cleavage and activation by CASP8, Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1, Regulates numerous cellular processes, Regulates transcription by direct phosphorylation of RNA polymerases I, SRF, STAT1, and inhibits the dimerization of CASP2 and activation of CASP8, apoptosis and transcription, as well as viral infection, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage, phosphorylates various proteins involved in the viral life cycles of EBV, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation, such as cell cycle progression, which is essential for chaperone function, Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | CK II alpha, CK2A1, CSNK2A1, CSNK2A3, Casein kinase II subunit alpha, CKII |
| Also known as | CK II alpha Polyclonal Antibody |
| Other name | Anti-CK II alpha Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | CK II alpha |
| Short name | Anti-CK II alpha (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-CK II a (polyclonal) |
| Alternative technique | polyclonals |