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Anti-CSEN (Ser63) (Polyclonal), ALEXA Fluor 594

Anti-CSEN (Ser63) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideCSEN Ser63
SpecificityThis antibody reacts specifically with CSEN (Ser63)
ModificationPhosphorylation
Modification siteSer63
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsMembrane bound
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human CSEN around the phosphorylation site of Ser63
Gene ID30818
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information DRE is a regulatory sequence that silences basal transcription and is localized to the promoter region of the gene encoding human prodynorphin, DREAM forms functional homotetramers that are required for the interaction with the DRE, DREAM has been shown to inhibit transcription of other proteins containing DRE-like motifs, DREAM transcripts are detected in brain, This association is highly influenced by calcium, an opioid peptide involved in memory acquisition and pain, and it is expressed as a nuclear protein, as an increase in Ca2+ directly inhibits DREAM binding and thereby blocks the repressor activity of DREAM, including the gene encoding for the AP-1 transcription factor c-Fos, suggesting that DREAM may influence a wide variety of cellular genes, thymus and thyroid gland, CSEN is a Ca2+-regulated transcriptional repressor that specifically binds to the downstream regulatory elements (DRE)
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms DREAM KCHIP3
Also known asCSEN (Ser63) Polyclonal Antibody
Other nameAnti-CSEN (Ser63) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetCSEN (Ser63)
Short nameAnti-CSEN (Ser63) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-CSEN (Ser63) (polyclonal)
Alternative techniquepolyclonals
Identity 15523
Gene KCNIP3
Long gene name potassium voltage-gated channel interacting protein 3
Synonyms gene CSEN
Synonyms gene name EF hand transcription factor Kv channel interacting protein 3, calsenilin, calsenilin , presenilin-binding protein
Synonyms name calsenilin
Locus 2q11, 1
Discovery year 2001-05-24
GenBank acession AF199599
Entrez gene record 30818
Pubmed identfication 9771752 10078534
RefSeq identity NM_013434
Classification Potassium voltage-gated channel regulatory subunits EF-hand domain containing
Havana BLAST/BLAT OTTHUMG00000130392

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