Filters

Anti-DCTN1 (Polyclonal), ALEXA Fluor 594

Anti-DCTN1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideDCTN1
SpecificityThis antibody reacts specifically with DCTN1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1
Gene ID1639
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information ALS is a neurodegenerative disorder affecting upper and lower motor neurons, Brain, Death usually occurs within 2 to 5 years, Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B), Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles, HMN7B is a neuromuscular disorder, Later on, Parkinsonism develops later and respiratory failure occurred terminally, Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, Sensory abnormalities are absent, The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs, The etiology is likely to be multifactorial, The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss, also called parkinsonism with alveolar hypoventilation and mental depression, also known as progressive lower motor neuron disease (PLMND), and resulting in fatal paralysis, exhaustion and marked weight loss, involving both genetic and environmental factors, sleep disturbances, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs, without sensory deficit in the posterior horn, Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS), Defects in DCTN1 are the cause of Perry syndrome (PERRYS), Involvement in disease, Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules, Tissue specificity
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asDCTN1 Polyclonal Antibody
Other nameAnti-DCTN1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetDCTN1
Short nameAnti-DCTN1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-DCTN1 (polyclonal)
Alternative techniquepolyclonals
Identity 2711
Gene DCTN1
Long gene name dynactin subunit 1
Synonyms gene name Glued (Drosophila) homolog) , dynactin 1 (p150
Synonyms name p150 glued homolog (Drosophila)
Locus 2p13, 1
Discovery year 1995-10-03
Entrez gene record 1639
Pubmed identfication 1828535
RefSeq identity NM_004082
Classification Dynactin
Havana BLAST/BLAT OTTHUMG00000129963
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_237

Similar products

Subscribe to our Newsletter