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Anti-DEDD2 (Polyclonal), ALEXA Fluor 594

Anti-DEDD2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideDEDD2
SpecificityThis antibody reacts specifically with DEDD2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human DEDD2
Gene ID162989
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information A novel death effector domain (DED)-containing protein, At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2, DEDD2, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, Like the related protein DEDD, More recently, Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis, has been recently identified, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD, Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms FLAME-3
Also known asDEDD2 Polyclonal Antibody
Other nameAnti-DEDD2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetDEDD2
Short nameAnti-DEDD2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-death effector domain containing 2 (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target DEDD2 and IDBG-53904 and ENSG00000160570 and 162989, DEDD2 and IDBG-638613 and ENSBTAG00000005761 and 534251, DNA-templated and biological process this GO :0006396 and RNA processing and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016075 and rRNA catabolic process and biological process this GO :0019725 and cellular homeostasis and biological process this GO :0030159 and receptor signaling complex scaffold activity and molecular function this GO :0030262 and apoptotic nuclear changes and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, Dedd2 and IDBG-156541 and ENSMUSG00000054499 and 67379, nuclei, receptor signaling complex scaffold activity, this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005730 and nucleolus and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0005515: protein binding and also this GO :0030159: receptor signaling complex scaffold activity, this GO :0005515: protein binding, this GO :0030159: receptor signaling complex scaffold activity, death effector domain containing 2
Identity 24450
Gene DEDD2
Long gene name death effector domain containing 2
Locus 19q13, 2
Discovery year 2004-02-10
GenBank acession AY125488
Entrez gene record 162989
Pubmed identfication 11965497 12235123
RefSeq identity NM_133328
Classification Death effector domain containing
Havana BLAST/BLAT OTTHUMG00000182763

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