Anti-DPYD (Polyclonal), ALEXA Fluor 594

Anti-DPYD (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	DPYD
Specificity	This antibody reacts specifically with DPYD
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human DPYD
Gene ID	1806
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs, DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU, DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU, Leukopenia, Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil, Specifically, This reaction includes stomatitis, Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene, a deficiency of DPYD leads to an accumulation of uracil and thymine, also known as hereditary thymine-uraciluria or familial pyrimidinemia, and neurologic symptoms, cerebellar ataxia, diarrhea, fever, hair loss, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression, marked weight loss, progressing to semicoma, thrombocytopenia, thus, thymine and 5-hydroxymethyluracil, Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine, Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency)
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	DPD
Also known as	DPYD Polyclonal Antibody
Other name	Anti-DPYD Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	DPYD
Short name	Anti-DPYD (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-DPYD (polyclonal)
Alternative technique	polyclonals
Identity	3012
Gene	DPYD
Long gene name	dihydropyrimidine dehydrogenase
Locus	1p21, 3
Discovery year	1994-07-07
GenBank acession	U20938
Entrez gene record	1806
Pubmed identfication	7713523
RefSeq identity	NM_000110
Havana BLAST/BLAT	OTTHUMG00000039683
Locus Specific Databases	UMD Locus Specific Databases LRG_722

Anti-DPYD (Polyclonal), ALEXA Fluor 594

Anti-DPYD (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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