Anti-EAAT4 (Polyclonal), ALEXA Fluor 594

Anti-EAAT4 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	EAAT4
Specificity	This antibody reacts specifically with EAAT4
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Extracellular
Antigen Source	KLH conjugated synthetic peptide derived from human EAAT4
Gene ID	6511
Swiss Prot	N/A
Applications	IF(IHC-P), FCM
Applications with corresponding dilutions	IF(IHC-P)(1:50-200), FCM(1:20-100)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Although EAAT5 shares the structural homologies of the EAAT family, EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum, EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina, EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering, a process that is essential for terminating the postsynaptic action of glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities, which is caused by the accumulation of amino acid neurotransmitters, Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	EAAT4
Also known as	EAAT4 Polyclonal Antibody
Other name	Anti-EAAT4 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	EAAT4
Short name	Anti-EAAT4 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-EAAT4 (polyclonal)
Alternative technique	polyclonals
Identity	10944
Gene	SLC1A6
Long gene name	solute carrier family 1 member 6
Synonyms gene name	member 6 , solute carrier family 1 (high affinity aspartate/glutamate transporter)
Locus	19p13, 12
Discovery year	1997-02-05
Entrez gene record	6511
Pubmed identfication	7791878
RefSeq identity	NM_005071
Classification	Solute carriers
Havana BLAST/BLAT	OTTHUMG00000183351

Anti-EAAT4 (Polyclonal), ALEXA Fluor 594

Anti-EAAT4 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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