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Anti-EIF4G1 (Ser1238) (Polyclonal), ALEXA Fluor 594

Anti-EIF4G1 (Ser1238) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideE4G1 Ser1238
SpecificityThis antibody reacts specifically with EIF4G1 (Ser1238)
ModificationPhosphorylation
Modification siteSer1238
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human EIF4G1 around the phosphorylation site of Ser1238
Gene ID1981
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information A domain at its N-terminus can also interact with the poly(A)-binding protein, Alternative splicing results in multiple transcript variants, Human eIF4G contains three consecutive HEAT domains, The interactions of eIF4G1 with other factors are largely unknown, The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex, The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex, This complex facilitates the recruitment of mRNA to the ribosome, Together with the cap-binding protein eIF4E, [provided by RefSeq], as well as long unstructured regions involved in multiple protein-protein interactions, eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network, it recruits the small ribosomal subunit to the 5'-end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon, some of which are derived from alternative promoter usage, which is a rate-limiting step during the initiation phase of protein synthesis, which may mediate the circularization of mRNA during translation, The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F, eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of mRNA to the ribosome
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms p220 PARK18
Also known asEIF4G1 (Ser1238) Polyclonal Antibody
Other nameAnti-EIF4G1 (Ser1238) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetEIF4G1 (Ser1238)
Short nameAnti-EIF4G1 (Ser1238) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-EIF4G1 (Ser1238) (polyclonal)
Alternative techniquepolyclonals
Identity 3296
Gene EIF4G1
Long gene name eukaryotic translation initiation factor 4 gamma 1
Synonyms gene EIF4G EIF4F
Synonyms gene name 1 , eukaryotic translation initiation factor 4 gamma
Locus 3q27, 1
Discovery year 1993-06-17
GenBank acession D12686
Entrez gene record 1981
Pubmed identfication 1429670 9372926 21907011
RefSeq identity NM_182917
Classification Parkinson disease associated genes
Havana BLAST/BLAT OTTHUMG00000156784

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