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Anti-EPS8 (Polyclonal), ALEXA Fluor 594

Anti-EPS8 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideEPS8
SpecificityThis antibody reacts specifically with EPS8
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from human EPS8
Gene ID2059
Swiss ProtQ12929
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context, Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, Also shows actin bundling activity when associated with BAIAP2, Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core, Depending on its association with other signal transducers, Displays barbed-end actin capping activity when associated with ABI1, In contrast, Indirectly involved in cell cycle progression, Involved in the regulation of processes such as axonal filopodia growth, Together with SOS1 and ABI1, can regulate different processes, dendritic cell migration and cancer cell migration and invasion, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation, its degradation following ubiquitination being required during G2 phase to promote cell shape changes, negatively regulates axonal filopodia formation via actin-capping activity, stereocilia length, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction, Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asEPS8 Polyclonal Antibody
Other nameAnti-EPS8 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetEPS8
Short nameAnti-EPS8 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-EPS8 (polyclonal)
Alternative techniquepolyclonals
Identity 3420
Gene EPS8
Long gene name epidermal growth factor receptor pathway substrate 8
Locus 12p12, 3
Discovery year 1994-12-19
GenBank acession U12535
Entrez gene record 2059
Pubmed identfication 8084614
Havana BLAST/BLAT OTTHUMG00000168787

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