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Anti-FAK(Tyr576 + Tyr577) (Polyclonal), ALEXA Fluor 594

Anti-FAK(Tyr576 + Tyr577) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideFAK Tyr576 + Tyr577
SpecificityFAK(Tyr576 + Tyr577), These phosphorylation sites are homologous to Tyr614 + Tyr615 in Mouse
ModificationPhosphorylation
Modification siteTyr576 + Tyr577
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Cell membrane, Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human FAK around the phosphorylation site of Tyr576/577
Gene ID5747
Swiss ProtQ05397
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information EPHA2, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in integrin signal transduction, G-protein coupled receptors (GPCR), MAPK3/ERK1 and the MAP kinase signaling cascade, P53/TP53 ubiquitination and proteasomal degradation, Plays a role in osteogenesis and differentiation of osteoblasts, Promotes activation of MAPK1/ERK2, Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade, Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates axon growth and neuronal cell migration, Regulates numerous signaling pathways, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, Signaling via CAS family members mediates activation of RAC1, adhesion, and normal heart development, and thereby modulates the activity of Rho family GTPases, and thereby regulates P53/TP53 activity, axon branching and synapse formation, but also in signaling downstream of numerous growth factor receptors, cell cycle progression, cell proliferation and apoptosis, creating binding sites for scaffold proteins, effectors and substrates, formation and disassembly of focal adhesions and cell protrusions, netrin receptors and LDL receptors, normal cardiomyocyte migration and proliferation, reorganization of the actin cytoskeleton, required for normal development of the nervous system, spreading, this leads to the phosphorylation of additional tyrosine residues, Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms FAK FADK FAK1 PPP1R71
Also known asFAK(Tyr576 + Tyr577) Polyclonal Antibody
Other nameAnti-FAK(Tyr576 + Tyr577) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetFAK(Tyr576 + Tyr577)
Short nameAnti-FAK(Tyr576 + Tyr577) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-FAK(Tyr576 and Tyr577) (polyclonal)
Alternative techniquepolyclonals
Identity 9611
Gene PTK2
Long gene name protein tyrosine kinase 2
Synonyms gene name PTK2 protein tyrosine kinase 2
Synonyms name protein phosphatase 1, regulatory subunit 71
Locus 8q24, 3
Discovery year 1992-10-02
GenBank acession L13616
Entrez gene record 5747
Pubmed identfication 8422239
RefSeq identity NM_005607
Classification Protein phosphatase 1 regulatory subunits FERM domain containing
Havana BLAST/BLAT OTTHUMG00000067438

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