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Anti-FGFR2 (Polyclonal), ALEXA Fluor 594

Anti-FGFR2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideFGFR2
SpecificityThis antibody reacts specifically with FGFR2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsExtracellular
Antigen SourceKLH conjugated synthetic peptide derived from human FGFR2
Gene ID2263
Swiss ProtP21802
ApplicationsFCM
Applications with corresponding dilutionsFCM(1:20-100)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR2 signaling is down-regulated by ubiquitination, FRS2 and PAK4, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, Over-expressed FGFR2 promotes activation of STAT1, PIK3R1 and SOS1, Phosphorylates PLCG1, Phosphorylation of FRS2 triggers recruitment of GRB2, Plays an essential role in the regulation of osteoblast differentiation, Promotes cell proliferation in keratinocytes and immature osteoblasts, Required for normal embryonic patterning, and in the regulation of embryonic development, and is required for normal skeleton development, and mediates activation of RAS, as well as of the AKT1 signaling pathway, but promotes apoptosis in differentiated osteoblasts, differentiation, internalization and degradation, internalization and degradation lead to aberrant signaling, limb bud development, lung morphogenesis, migration and apoptosis, osteogenesis and skin development, proliferation and apoptosis, trophoblast function, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms CEK3 TK14 TK25 ECT1 K-SAM CD332
Also known asFGFR2 Polyclonal Antibody
Other nameAnti-FGFR2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetFGFR2
Short nameAnti-FGFR2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-FGFR2 (polyclonal)
Alternative techniquepolyclonals
Identity 3689
Gene FGFR2
Long gene name fibroblast growth factor receptor 2
Synonyms gene KGFR BEK CFD1 JWS
Synonyms gene name bacteria-expressed kinase keratinocyte growth factor receptor craniofacial dysostosis 1 Jackson-Weiss syndrome
Synonyms name Crouzon syndrome Pfeiffer syndrome
Locus 10q26, 13
Discovery year 1991-05-09
GenBank acession AK026508
Entrez gene record 2263
RefSeq identity NM_022976 NM_000141
Classification I-set domain containing CD molecules Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000019175
Locus Specific Databases LRG_994

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