Anti-FGFR4/CD334 (Polyclonal), ALEXA Fluor 594

Anti-FGFR4/CD334 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	FGFR4/CD334
Specificity	This antibody reacts specifically with FGFR4/CD334
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Extracellular
Antigen Source	KLH conjugated synthetic peptide derived from human FGFR4
Gene ID	2264
Swiss Prot	P22455
Applications	IF(IHC-P), FCM
Applications with corresponding dilutions	IF(IHC-P)(1:50-200), FCM(1:20-100)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR4 signaling is down-regulated by receptor internalization and degradation, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling, PIK3R1 and SOS1, Phosphorylates PLCG1 and FRS2, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, Required for normal down-regulation of the expression of CYP7A1, and in regulation of lipid metabolism, and mediates activation of RAS, as well as of the AKT1 signaling pathway, bile acid biosynthesis, differentiation and migration, glucose uptake, in response to FGF19, the rate-limiting enzyme in bile acid synthesis, vitamin D metabolism and phosphate homeostasis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	JTK2 CD334
Also known as	FGFR4/CD334 Polyclonal Antibody
Other name	Anti-FGFR4/CD334 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	FGFR4/CD334
Short name	Anti-FGFR4/CD334 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-FGFR4/CD334 (polyclonal)
Alternative technique	polyclonals
Identity	3691
Gene	FGFR4
Long gene name	fibroblast growth factor receptor 4
Locus	5q35, 2
Discovery year	1991-07-25
GenBank acession	AF202063
Entrez gene record	2264
Classification	I-set domain containing CD molecules Receptor Tyrosine Kinases
Havana BLAST/BLAT	OTTHUMG00000151523

Anti-FGFR4/CD334 (Polyclonal), ALEXA Fluor 594

Anti-FGFR4/CD334 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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