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Anti-GAD67 (Polyclonal), ALEXA Fluor 594

Anti-GAD67 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideGAD67/GAD1
SpecificityBelongs to the group II decarboxylase family, GAD67
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human GAD67
Gene ID2571
Swiss ProtQ99259
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information (585 amino acid residues) and is encoded on human chromosome 10, GAD exists as two isoforms, GAD has a restricted tissue distribution, GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, GAD65 and GAD67 (molecular masses of 65 and 67 kD, GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), GAD65 is an ampiphilic, GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2, IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells, Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms, It is also present in other non-neuronal tissues such as testis, It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells, The two isoforms appear to have distinct intraneuronal distribution in the brain, There is 64% amino acid identity between the two isoforms, This suggests that GAD may be an important marker in the early stages of the disease, and a putative paracrine signal molecule in pancreatic islets, membraneanchored protein, oviduct and ovary, respectively) that are encoded by two different genes, suggesting its involvement in development and plasticity, the principal inhibitory neurotransmitter in the brain, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles, with the highest diversity located at the N terminus, Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA)
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms 67 kDa glutamic acid decarboxylase, CPSQ1, GAD-67, GAD1, GAD67, Glutamate decarboxylase 1, Glutamate decarboxylase 67 kDa isoform, SCP, GAD
Also known asGAD67 Polyclonal Antibody
Other nameAnti-GAD67 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetGAD67
Short nameAnti-GAD67 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-GAD67 (polyclonal)
Alternative techniquepolyclonals

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