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Anti-Gemin 1/SMA (Polyclonal), ALEXA Fluor 594

Anti-Gemin 1/SMA (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideGemin 1/SMA
SpecificityThis antibody reacts specifically with Gemin 1/SMA
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human Gemin 1
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Cytoplasmic SMN interacts with spliceosomal Sm proteins and facilitates their assembly onto U snRNAs, Gemin3 (a DEAD box RNA helicase), Gemin4, Gemin5 and Gemin6, Nearly identical telomeric and centromeric forms of SMN encode the same protein, SMA is caused by deletion or loss-of-function mutations of SMN (survival of motor neuron) gene, SMN, SMN is expresed in a wide variety of tissues including brain, SMN is oligomeric and forms a complex with Gemin2 (formerly SIP1), SMN1, SMNT and BCD541, The SMN complex is found in both the cytoplasm and the nucleus, The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus, The nuclear form is concentrated in subnuclear bodies called gems (gemini of the coiled bodies), also known as Gemin1, and nuclear SMN mediates recycling of pre-mRNA splicing factors, as well as several spliceosomal snRNP proteins, exists as four isoforms produced by alternative splicing, however, kidney, liver, only mutations in the telomeric form are associated with the disease-state SMA, spinal cord and moderately in skeletal and cardiac muscle, Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A
Also known asGemin 1/SMA Polyclonal Antibody
Other nameAnti-Gemin 1/SMA Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetGemin 1/SMA
Short nameAnti-Gemin 1/SMA (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-Gemin 1/SMA (polyclonal)
Alternative techniquepolyclonals
Identity 11117
Gene SMN1
Long gene name survival of motor neuron 1, telomeric
Synonyms gene SMA@ SMA
Synonyms gene name Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease
Synonyms name gemin-1 tudor domain containing 16A
Locus 5q13, 2
Discovery year 1996-12-12
GenBank acession U18423
Entrez gene record 6606
Pubmed identfication 7813012
RefSeq identity NM_000344
Classification Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000099361
Locus Specific Databases SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676

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