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Anti-GLCNE (Polyclonal), ALEXA Fluor 594

Anti-GLCNE (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideGLCNE
SpecificityThis antibody reacts specifically with GLCNE
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human GLCNE
Gene ID10020
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterized by adult onset, Defects in GLCNE are the cause of sialuria, GLCNE is required for normal sialylation in hematopoietic cells, It is also expressed, It is characterized by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine, It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta, Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, Sialylation is implicated in cell adhesion, a precursor of sialic acids, brain, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles, in heart, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV), kidney, lung, or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), resulting in overproduction of NeuAc, signal transduction, skeletal muscle and pancreas, to a lesser extent, tumorigenicity and metastatic behavior of malignant cells, The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk)
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms Bunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase, DMRV, GLCNE_HUMAN, ManAc kinase, N acylmannosamine kinase, NM, RP23-209M8, UDP GlcNAc 2 epimerase, UDP GlcNAc 2 epimerase/ManAc kinase, Uae1, Uridine diphosphate N acetylglucosamine 2 epimerase, 6, IBM2
Also known asGLCNE Polyclonal Antibody
Other nameAnti-GLCNE Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetGLCNE
Short nameAnti-GLCNE (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-GLCNE (polyclonal)
Alternative techniquepolyclonals

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