Name : Anti-GNRHR2 (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :489
SKU : GEN7093636111
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | GNRHR2 |
| Specificity | This antibody reacts specifically with GNRHR2 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Extracellular |
| Antigen Source | KLH conjugated synthetic peptide derived from human GNRHR2 |
| Gene ID | N/A |
| Swiss Prot | N/A |
| Applications | IF(IHC-P), FCM |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species | Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | Due to alternative splicing events, GnRHR2 is expressed as two isoforms, GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, GnRHR2 mediates its own receptor activity via association with G proteins, Localized to the cell membrane, This hypothalamic hormone is transported to the pituitary, suggesting a possible role in tumor suppression, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Also known as | GNRHR2 Polyclonal Antibody |
| Other name | Anti-GNRHR2 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | GNRHR2 |
| Short name | Anti-GNRHR2 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-GNRHR2 (polyclonal) |
| Alternative technique | polyclonals |
| Identity | 16341 |
| Gene | GNRHR2 |
| Long gene name | gonadotropin releasing hormone receptor 2 (pseudogene) |
| Synonyms gene name | gonadotropin-releasing hormone (type 2) receptor 2 |
| Locus | 1q21, 1 |
| Discovery year | 2001-09-26 |
| GenBank acession | AF403014 |
| Entrez gene record | 114814 |
| Pubmed identfication | 11707068 |
| RefSeq identity | NR_002328 |
| Classification | Gonadotropin releasing hormone receptors |
| Havana BLAST/BLAT | OTTHUMG00000013742 |