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Anti-GRIK2/GLR6 (Polyclonal), ALEXA Fluor 594
Anti-GRIK2/GLR6 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489
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BIOSS POLYCLONAL ANTIBODIES
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489
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100 microliters
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| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | GRIK2/GLR6 |
| Specificity | This antibody reacts specifically with GRIK2/GLR6 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Extracellular |
| Antigen Source | KLH conjugated synthetic peptide derived from human GRIK2/GLR6 |
| Gene ID | N/A |
| Swiss Prot | N/A |
| Applications | IF(IHC-P), FCM |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | 2, 3, 4 and one zeta subunit, Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7, The NMDA receptors consist of five subunits: epsilion 1, The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, The zeta subunit is expressed throughout the brainstem, both of which contain glutamate-gated, cation-specific ion channels, neural development and neurodegeneration, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions, whereas the four epsilon subunits display limited distribution, Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | GluK5 KA2 |
| Also known as | GRIK2/GLR6 Polyclonal Antibody |
| Other name | Anti-GRIK2/GLR6 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | GRIK2/GLR6 |
| Short name | Anti-GRIK2/GLR6 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, ionotropic, kainate 2/GLR6 (polyclonal), antibody to-glutamate receptor |
| Alternative technique | polyclonals |
| Alternative to gene target | Cell surfaces, EAA4 and GLR6 and GluK2 and GLUK6 and GLUR6 and MRT6, GRIK2 and IDBG-631973 and ENSBTAG00000033153 and 615226, GRIK2 and IDBG-94705 and ENSG00000164418 and 2898, Grik2 and IDBG-149430 and ENSMUSG00000056073 and 14806, glutamatergic and biological process this GO :0042391 and regulation of membrane potential and biological process this GO :0042734 and presynaptic membrane and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043113 and receptor clustering and biological process this GO :0043195 and terminal bouton and cellular component this GO :0043204 and perikaryon and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0046328 and regulation of JNK cascade and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048172 and regulation of short-term neuronal synaptic plasticity and biological process this GO :0050804 and regulation of synaptic transmission and biological process this GO :0050806 and positive regulation of synaptic transmission and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051967 and negative regulation of synaptic transmission, glutamatergic and biological process this GO :0060079 and regulation of excitatory postsynaptic membrane potential and biological process this GO :0060080 and regulation of inhibitory postsynaptic membrane potential and biological process, ionotropic, kainate 2, protein homodimerization activity, this GO :0001662 and behavioral fear response and biological process this GO :0004970 and ionotropic glutamate receptor activity and molecular function this GO :0005215 and transporter activity and molecular function this GO :0005234 and extracellular-glutamate-gated ion channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006810 and transport and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0007165 and signal transduction and biological process this GO :0007215 and glutamate receptor signaling pathway and biological process this GO :0007268 and synaptic transmission and biological process this GO :0008066 and glutamate receptor activity and molecular function this GO :0008328 and ionotropic glutamate receptor complex and cellular component this GO :0014069 and postsynaptic density and cellular component this GO :0015277 and kainate selective glutamate receptor activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019228 and neuronal action potential and biological process this GO :0030054 and cell junction and cellular component this GO :0030165 and PDZ domain binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031624 and ubiquitin conjugating enzyme binding and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032839 and dendrite cytoplasm and cellular component this GO :0032983 and kainate selective glutamate receptor complex and cellular component this GO :0034220 and ion transmembrane transport and biological process this GO :0035235 and ionotropic glutamate receptor signaling pathway and biological process this GO :0035249 and synaptic transmission, this GO :0004970: ionotropic glutamate receptor activity, this GO :0004970: ionotropic glutamate receptor activity and also this GO :0005215: transporter activity and also this GO :0005234: extracellular-glutamate-gated ion channel activity and also this GO :0005515: protein binding and also this GO :0008066: glutamate receptor activity and also this GO :0015277: kainate selective glutamate receptor activity and also this GO :0030165: PDZ domain binding and also this GO :0031624: ubiquitin conjugating enzyme binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0042802: identical protein binding and also this GO :0042803: protein homodimerization activity, this GO :0005215: transporter activity, this GO :0005234: extracellular-glutamate-gated ion channel activity, this GO :0005515: protein binding, this GO :0008066: glutamate receptor activity, this GO :0015277: kainate selective glutamate receptor activity, this GO :0030165: PDZ domain binding, this GO :0031624: ubiquitin conjugating enzyme binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0042802: identical protein binding, this GO :0042803: protein homodimerization activity, glutamate receptor |
| Identity | 4583 |
| Gene | GRIK5 |
| Long gene name | glutamate ionotropic receptor kainate type subunit 5 |
| Synonyms gene | GRIK2 |
| Synonyms gene name | glutamate receptor, ionotropic, kainate 5 |
| Locus | 19q13, 2 |
| Discovery year | 1993-10-21 |
| Entrez gene record | 2901 |
| Pubmed identfication | 7527545 |
| Classification | Glutamate ionotropic receptor kainate type subunits |
| Havana BLAST/BLAT | OTTHUMG00000044573 |