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Anti-GSK-3 Beta(Ser21) (Polyclonal), ALEXA Fluor 594

Anti-GSK-3 Beta(Ser21) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideGSK-3 Beta Ser21
SpecificityThis antibody reacts specifically with GSK-3 Beta(Ser21)
ModificationPhosphorylation
Modification siteSer21
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Cell membrane, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Ser21
Gene ID2932
Swiss ProtP49841
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information APC, AXIN1, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes, CTNNB1/beta-catenin, DPYSL2/CRMP2, EIF2B, GSK3B forms a multimeric complex with APC, In Wnt signaling, In skeletal muscle, JUN, MAPT/TAU and MACF1, MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease, May also mediate the development of insulin resistance by regulating activation of transcription factors, NFATC1/NFATC, Phosphorylates JUN at sites proximal to its DNA-binding domain, Phosphorylates MACF1, Phosphorylates MAPT/TAU on 'Thr-548', Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex, Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA), Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase, Requires primed phosphorylation of the majority of its substrates, Wnt signaling and regulation of transcription factors and microtubules, and thereby opposing the action of calcineurin, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair, shutting off NFATC1/NFATC gene regulation, thereby reducing its affinity for DNA, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms GSK-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, Glycogen synthase kinase-3 beta
Also known asGSK-3 Beta(Ser21) Polyclonal Antibody
Other nameAnti-GSK-3 Beta(Ser21) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetGSK-3 Beta(Ser21)
Short nameAnti-GSK-3 Beta(Ser21) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-GSK-3 b(Ser21) (polyclonal)
Alternative techniquepolyclonals

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